Resources
Research and Supporting Documents for 'Same Kind or Class' Designation
Debilitating anxiety has comparable symptoms found in post-traumatic stress disorder patients.
https://adaa.org/understanding-anxiety/posttraumatic-stress-disorder-ptsd
http://www.ptsd.ne.gov/what-is-ptsd.html
Summary:
Cannabidiols reduces anxiety in patients with generalized social anxiety disorder and improves sleep or rest. Data suggests it may dampen the intensity or emotional impact of traumatic memories and less involved flashback memories in people with post-traumatic stress disorder.
https://www.ncbi.nlm.nih.gov/pubmed/21307846
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691841/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998228/
Alzheimer's disease and post-traumatic stress disorder cause similar symptoms including debilitating anxiety, depression and/or irritability.
Citations:
https://www.alz.org/professionals_and_researchers_behavioral_symptoms_pr.asp
http://www.ptsd.ne.gov/what-is-ptsd.html
Summary:
Data strongly suggests that THC could be a potential therapeutic treatment option for Alzheimer's disease through multiple functions and pathways. Low doses of THC can enhance mitochondria function and does not inhibit melatonin's enhancement of mitochondria function. No toxicity was observed at treatment concentrations, and the CB1 receptor was not significantly upregulated.
Med Lit Links:
https://www.ncbi.nlm.nih.gov/pubmed/25024327
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad140093
Anorexia / loss of appetite has debilitating symptoms comparable to those seen in HIV/AIDS
Citation:
http://www.who.int/hac/techguidance/pht/8518.pdf?ua=1
Summary:
Cannabis is the only antiemetic that increases appetite as well as being less potent than other available antiemetics, and for some patients it is the only agent that works.
Med Lit Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791148/
https://www.ncbi.nlm.nih.gov/pubmed/11362196
http://www.jpsmjournal.com/article/0885-3924(94)00117-4/pdf
Joint inflammation and pain associated with arthritis is comparable to that seen in multiple sclerosis.
Citation:
http://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Pain
Summary:
Autoimmune inflammation is suppressed by several cannabinoid receptors on autoreactive cells. Cannabinoids can play a protective role in autoimmune conditions and are well-known for their anti-inflammatory effects.
Med Lit Link:
https://www.ncbi.nlm.nih.gov/pubmed/22530636
Asthma is a debilitating condition with shortness of breath and other symptoms comparable to those seen in patients with post-traumatic stress disorder (PTSD) and lung cancer.
Citation:
https://www.sciencedaily.com/releases/2007/11/071115091713.htm
https://www.lungcancer.org/find_information/publications/163-lung_cancer_101/266-symptoms
Summary:
Several studies have shown that administration of cannabis in various forms can significantly improve bronchoconstriction both during an asthma attack and in normal circumstances. Furthermore, cannabis is currently being investigated for its ability to produce targeted therapies for immune-modulated inflammatory diseases.
Med Lit Links:
https://sensiseeds.com/en/blog/top-6-benefits-of-cannabis-for-asthma/
Autism is similar to post-traumatic stress disorder in that it is a debilitating condition with symptoms that include anxiety, panic attacks, disruptive and violent behaviors, insomnia, and irritability. Symptoms may also include a decreased ability to communicate (comparable to what is seen in Parkinson's Disease and ALS).
Citations:
https://www.autismspeaks.org/what-autism/symptoms
https://scienceofparkinsons.com/2016/05/22/the-autistic-spectrum-and-parkinsons-disease/
Summary:
One particular case study involving a young male with autism treated with daily dronabinol [synthetic thc] was noted to have improvement in hyperactivity, irritability, lethargy, stereotyped behaviors and speech following six months of treatment.
Med Lit Link:
https://www.ncbi.nlm.nih.gov/pubmed/28861483
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137184/
Biopolar Disorder and post-traumatic stress disorder similarly produce debilitating irritability, anxiety or depression.
Citations:
https://adaa.org/understanding-anxiety/related-illnesses/bipolar-disorder#CoOccurring
http://www.psychiatrictimes.com/bipolar-disorder/anxious-bipolar-patient
Summary:
Case histories presented by the authors indicate that a number of patients find cannabis useful in the treatment of their bipolar disorder to treat mania, depression, or both. Patients stated that it was more effective than conventional drugs, or helped relieve the side effects of conventional drugs . Some patients described the use of cannabis as a supplement to lithium for relief of lithium's side effects or allowing reduced consumption of lithium.
Med Lit Links:
https://www.ncbi.nlm.nih.gov/pubmed/9692379
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408776/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898690/
Chronic fatigue syndrome and multiple sclerosis are both diseases of the central nervous system, comparable in that both conditions have similar debilitating symptoms of muscular pain, decreased energy, and chronic fatigue.
Citation:
https://www.ncbi.nlm.nih.gov/pubmed/25238862
https://www.ncbi.nlm.nih.gov/pubmed/24229326
Summary:
Cannabis use was associated with beneficial effects on some fibromyalgia symptoms.
MedLit Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080871/
Chronic nausea is an incapacitating symptom comparable that which is seen in HIV/AIDS and cancer.
Citations:
https://aidsetc.org/guide/nausea-and-vomiting
https://www.cancer.org/treatment/treatments-and-side-effects/physical-side-effects/nausea-and-vomiting/what-is-it.html
Summary:
Considerable evidence demonstrates manipulation of the endocannabinoid system regulates nausea and vomiting.
Med Lit Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165951/
Chronic pain is a debilitating symptom comparable to that which is seen in multiple sclerosis.
Citations:
http://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Pain
https://www.msif.org/about-ms/symptoms-of-ms/pain/
Summary:
97% of respondents used medical cannabis primarily for relief of chronic pain.
Med Lit Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998228/
https://www.ncbi.nlm.nih.gov/pubmed/16186518
https://www.ncbi.nlm.nih.gov/pubmed/16988792
https://www.ncbi.nlm.nih.gov/books/NBK395793/#S15
Depression disorder has debilitating symptoms comparable to symptoms seen in PTSD.
Citations:
https://www.adaa.org/understanding-anxiety/posttraumatic-stress-disorder-ptsd
Summary:
Users reported more positive affect and less depression when used daily than non-users.
Med Lit Link:
https://www.ncbi.nlm.nih.gov/pubmed/15964704
Fibromyalgia produces debilitating symptoms of muscle pain and chronic fatigue comparable to that experienced in multiple sclerosis.
Citation:
http://www.fibromyalgia-symptoms.org/similarities-fibromyalgia-multiple-sclerosis.html
Summary:
Research confirms that underlying endocannabinoid deficiencies play a role in fibromyalgia and the chronic fatigue and muscle pain associated with these conditions.
Med Lit Links:
https://www.ncbi.nlm.nih.gov/pubmed/24977967
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080871/
https://www.ncbi.nlm.nih.gov/pubmed/28857069
Chronic headaches, a debilitating symptom is comparable to that which is commonly seen in multiple sclerosis.
Citations:
http://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Headache
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883008/
Summary:
Medicinal use of cannabis may have a therapeutic role for a multitude of diseases, particularly chronic pain disorders including headache as suggested by the corresponding literature.
Med Lit Links:
https://www.ncbi.nlm.nih.gov/pubmed/26015168
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484259/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436334/
Huntington's Disease like Parkinson's Disease is a movement disorder.
Citation:
http://www.pmdi.org/movement-disorders.html
Summary:
A synthetic cannabinoid called Nabilone has shown treatment difference for total motor score and chorea, uhdrs cognition and uhdrs behavior verse placebo treatment.
Med Lit Link:
https://www.ncbi.nlm.nih.gov/pubmed/19845035
Attention and concentration deficit symptoms, cognition changes, less focus and concentration (inattentive, absent mindedness) are debilitating symptoms comparable to that which is seen in Parkinson's and HIV/AIDS.
Citations:
https://www.apdaparkinson.org/what-is-parkinsons/symptoms/personality-change/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108270/
Summary:
Literature reports other therapeutic benefits include increased focus/concentration (9%).
Med LitLink:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998228/
Insomnia is a debilitating condition with symptoms comparable to those seen in post-traumatic stress disorder (PTSD).
Citation:
https://www.ncbi.nlm.nih.gov/pubmed/16800716
Med Lit Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165471/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998228/
Irritable bowel syndrome (IBS) is a debilitating gastrointestinal disorder with symptoms comparable to those seen in Crohn's disease.
Citations:
https://irritablebowelsyndrome.net/what-is-ibs/similarities-differences-between-ibd-ibs/
https://www.everydayhealth.com/hs/crohns-disease-treatment-management/crohns-ibs/
Summary:
The marijuana plant cannabis sativa has been reported to produce beneficial effects for patients with inflammatory bowel diseases.
Med Lit Links:
https://www.karger.com/Article/Abstract/358155
http://ajpgi.physiology.org/content/311/4/G655
Lupus is a debilitating inflammatory autoimmune diseases with comparable symptoms as seen in multiple sclerosis.
Citations:
https://www.ncbi.nlm.nih.gov/pubmed/24238696
http://www.neurologyadvisor.com/multiple-sclerosis/genetic-variant-link-found-for-ms-system-lupus/article/653285/
Summary:
Ajulemic acid (AJA), a synthetic cannabinoid reduced the secretion of IL-6 from activated cells. This suggests that AJA may be a treatment option for joint inflammation in patients with systemic lupus erythematosus.
Med Lit Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679081/
http://online.liebertpub.com/doi/10.1089/can.2017.0028
Chronic migraines may create incapacitating symptoms comparable to those seen in multiple sclerosis.
Citation:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883008/
Summary:
The frequency of migraine headache was decreased with medical marijuana use.
Med Lit Link:
https://www.ncbi.nlm.nih.gov/pubmed/26749285
Obsessive-compulsive disorder (OCD) is comparable to the debilitating obsessive/compulsive symptoms of posttraumatic stress disorder (PTSD).
Citation:
https://psychcentral.com/lib/differential-diagnosis-of-ptsd-symptoms/
Summary:
Motor tic severity and obsessive-compulsive symptoms were considerably improved by THC.
Med Lit Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036957/
Rheumatoid arthritis and multiple sclerosis share many pathophysiologic and etiologic features including debilitating chronic pain. Rheumatoid, multiple sclerosis, Crohn's disease and rheumatoid arthritis are comparable in that they are all autoimmune diseases.
Citations:
https://www.niams.nih.gov/Health_info/Autoimmune/default.asp#2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937922/
Summary:
Ajulemic acid (AJA), a synthetic cannabinoid reduced the secretion of IL-6 from activated cells. This suggests that AJA may be a treatment option for joint inflammation in patients with systemic lupus erythematosus.
Med Lit Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453762/
https://www.ncbi.nlm.nih.gov/pubmed/28945457
Tourette's Syndrome and Parkinson's Disease are comparable in that they both are movement disorders.
Citation:
http://www.pmdi.org/movement-disorders.html
Summary:
Both motor tic severity and obsessive compulsive symptoms were significantly improved by THC. Tics, usually due to Tourette's, did respond to cannabis preparations.
Med Lit Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036957/
https://www.ncbi.nlm.nih.gov/pubmed/26271953
Ulcerative colitis is a debilitating inflammatory bowel disease with comparable symptoms as seen in Crohn's disease.
Citations:
https://www.ncbi.nlm.nih.gov/pubmed/21795981
https://www.omicsonline.org/open-access/pathogenesis-of-ulcerative-colitis-and-crohns-disease-2155-9899.1000253.php?aid=30487
Summary:
Non-psychotropic cannabinoid cannabigerol had beneficial effect on experimental inflammatory bowel disease.
Med Lit Links:
https://www.ncbi.nlm.nih.gov/pubmed/23648372
https://www.karger.com/Article/Abstract/358155
http://ajpgi.physiology.org/content/311/4/G655
https://www.ncbi.nlm.nih.gov/pubmed/27846066
Neuropathic pain
Incapacitating neuropathic pain and symptoms are comparable to that seen in Multiple Sclerosis.
Citations:
https://www.nationalmssociety.org/symptoms-diagnosis/MS-Symptoms/Pain
https://www.msif.org/about-ms/symptoms-of-ms/pain/
Neuropathic Pain SUMMARY:
Numerous randomized clinical trials have demonstrated safety and efficacy for Sativex in central and peripheral neuropathic pain, rheumatoid arthritis and cancer pain.
Med Lit Links:
Osteoarthritis:
Osteoarthritis is an incapacitating degenerative bone and joint disease with symptoms comparable to those associated with bone cancer.
Citations:
https://www.cancercenter.com/cancer-types/bone-cancer/symptoms
Osteoarthritis
Summary:
Favorable results in the therapeutic value of cannabinoids for osteoarthritis have been recognized.
Med Ut Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453762/
LOW BACK PAIN
Chronic and acute lower back pain is a debilitating symptom comparable to the low back pain/musculoskeletal pain seen in patients with Multiple Sclerosis.
Citations:
https://www.msif.org/about-ms/symptoms-of-ms/pain/
LOW BACK PAIN SUMMARY:
Clinical and preclinical data suggests that cannabinoids, derived from the Cannabis Sativa plant, may be used to control symptoms of chronic pain and spasticity. Objective measures of pain intensity are significantly reduced with inhaled cannabis compared to placebo in Multiple Sclerosis patients.
Med Lit Links:
https://www.ncbi.nlm.nih.gov/pubmed/15258006
https://www.ncbi.nlm.nih.gov/pubmed/27831665
Muscle Spasms
Coping with stiff, aching, cramping muscles is a way of life for most of the 2.5 million people in the world who have multiple sclerosis. Many of the 15 million people with spinal cord injuries also suffer from the same symptoms, which cause pain, limit movement, and rob people of needed sleep. In a 1982 survey of people with spinal cord injuries, 21 of 43 respondents reported that marijuana reduced muscle spasticity1 (a condition in which muscles tense reflexively and resist stretching), while nearly every participant in a 1997 survey of 112 regular marijuana users with multiple sclerosis replied that the drug lessened both pain and spasticity.
Malec J, Harvey RF, Cayner JJ. 1982. “Cannabis effect on spasticity in spinal cord injury.” Archives of Physical Medicine and Rehabilitation 63:116-118.
BMC Neurol. 2009 Dec 4;9:59. doi: 10.1186/1471-2377-9-59.
Summary:
https://www.ncbi.nlm.nih.gov/books/NBK224382/